Predictive Effects of FT3/FT4 on Diabetic Kidney Disease: An Exploratory Study on Hospitalized Euthyroid Patients with T2DM in China

Objective: This study aims to explore the correlation between free-triiodothyronine (FT3)-to-free-thyroxine (FT4) ratio (FT3/FT4) and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). Methods: retrospectively analyzed 1729 T2DM hospitalized Department of Endocrinology, Peking University International Hospital, from January 2017 August 2021, including 1075 males 654 females. In accordance FT3/FT4, were divided into three groups. Results: (1) The levels glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG) postprandial (PBG) among groups significantly different, low FT3/FT4 group having highest HbA1c, FBG PBG (F = 39.39, p < 0.01; F 27.04, 5.76, 0.03; respectively). (2) proportion DKD is lowest high (χ2 25.83, 0.01). (3) Logistic regression showed that independent risk factors for (OR 2.36, 95 CI% 1.63, 3.43; Conclusion: A decrease an predictor occurrence T2DM.